Bio-Inspired Glucose Control in Diabetes Based on an Analogue Implementation of a -Cell Model

Abstract—This paper presents a bio-inspired method for in-vivo control of blood glucose based on a model of the pancreatic β-cell. The proposed model is shown to be implementable using low-power analogue integrated circuits in CMOS, realizing a biologically faithful implementation which captures all the behaviours seen in physiology. This is then shown to be capable of glucose control using an in silico population of diabetic < Final Year Projects >subjects achieving 93% of the time in tight glycemic target (i.e., [70, 140] mg/dl) . The proposed controller is then compared with a commonly used external physiological insulin delivery (ePID) controller for glucose control. Results confirm equivalent, or superior, performance in comparison with ePID. The system has been designed in a commercially available 0.35 μm CMOS process and achieves an overall power consumption of 1.907 mW.